The extracellular matrix: Tools and insights for the “omics” era
Massachusetts Institute of Technology · Broad Institute · +1 more institution
Abstract
The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyperproduction or alteration of the composition of the ECM cause or accompany numerous pathologies. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities. The development over the last few years of high-throughput ("omics") approaches has considerably accelerated the pace of discovery in life sciences. In this review, we describe new bioinformatic tools and experimental strategies…
Citation impact
- FWCI
- 28.18
- Percentile
- 100%
- References
- 109
Authors
6Topics & keywords
- Extracellular matrix
- Omics
- Computational biology
- Computer science
- Data science
- Biology
- Bioinformatics
- Cell biology
- Responsible consumption and production
Funding
- HHHoward Hughes Medical Institute
- UOUniversity of Pittsburgh
- BIBroad Institute
- KIKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyAward: P30-CA14051
- NCNational Cancer Institute, Cairo UniversityAward: P30-CA14051
- NCNational Cancer InstituteAwards: U54 CA126515, P30-CA14051, CA14051