Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings §Δ

UNLABELLED: The diagnosis of nonalcoholic steatohepatitis (NASH) is defined by the presence and pattern of specific histological abnormalities on liver biopsy. A separate system of scoring the features of nonalcoholic fatty liver disease (NAFLD) called the NAFLD Activity Score (NAS) was developed as a tool to measure changes in NAFLD during therapeutic trials. However, some studies have used threshold values of the NAS, specifically NAS ≥5, as a surrogate for the histologic diagnosis of NASH. To evaluate whether this unintended use of the NAS is valid, biopsy and clinical data from the 976 adults in NASH Clinical Research Network (CRN) studies were reviewed. Biopsies were evaluated centrally by the NASH CRN…

• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: U01DK061718, U01DK061734, U01DK061731, U01DK061713, U01DK061738, U01DK061737, U01DK061718, U01DK061728, U01DK061731, U01DK061732, U01DK061728, grants U01DK061718, U01DK061728, U01DK061731, U01DK061732, U01DK061734, U01DK061737, U01DK061738, U01DK061730, U01DK061713, U01DK061730, U01DK061732
• NI
  National Institute of Child Health and Human Development

  Awards: U01DK061737, U01DK061718, U01DK061728, U01DK061734, U01DK061713, U01DK061732, U01DK061731, U01DK061738, U01DK061730