Histiocytic Disorders and Treatments

This cluster of papers focuses on the classification, diagnosis, and treatment of histiocytic disorders, including Langerhans Cell Histiocytosis and Erdheim-Chester Disease. It explores the role of BRAF mutations, immunohistochemical approaches to classification, and consensus guidelines for clinical management. The papers also delve into the pathogenesis, molecular characterization, and therapy intensification for multisystem involvement.