Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
University of Padua · National Academies of Sciences, Engineering, and Medicine · +3 more institutions
Abstract
The organization and mutual interactions between endoplasmic reticulum (ER) and mitochondria modulate key aspects of cell pathophysiology. Several proteins have been suggested to be involved in keeping ER and mitochondria at a correct distance. Among them, in mammalian cells, mitofusin 2 (Mfn2), located on both the outer mitochondrial membrane and the ER surface, has been proposed to be a physical tether between the two organelles, forming homotypic interactions and heterocomplexes with its homolog Mfn1. Recently, this widely accepted model has been challenged using quantitative EM analysis. Using a multiplicity of morphological, biochemical, functional, and genetic approaches, we demonstrate that Mfn2…
Citation impact
- FWCI
- 24.69
- Percentile
- 100%
- References
- 41
Authors
6- RFRiccardo FiladiCorresponding
University of Padua
- EGElisa Greotti
University of Padua, National Academies of Sciences, Engineering, and Medicine, National Research Council
- GTGabriele Turacchio
National Academies of Sciences, Engineering, and Medicine, Institute of Protein Biochemistry, National Research Council
- ALAlberto Luini
National Academies of Sciences, Engineering, and Medicine, Institute of Protein Biochemistry, National Research Council
- TPTullio Pozzan
University of Padua, National Academies of Sciences, Engineering, and Medicine, Veneto Institute of Molecular Medicine, National Research Council
Topics & keywords
- MFN2
- Endoplasmic reticulum
- Mitochondrion
- Cell biology
- Mitophagy
- Organelle
- Bioenergetics
- Chemistry