The IGF‐1 receptor in cancer biology
Thomas Jefferson University · Sidney Kimmel Cancer Center · +1 more institution
Indexed incrossrefpubmed
Abstract
The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.
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644
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Authors
3Topics & keywords
Topics
Keywords
- Downregulation and upregulation
- Insulin-like growth factor
- Receptor
- Biology
- Cancer
- Phenotype
- Insulin-Like Growth Factor Receptor
- Apoptosis
UN Sustainable Development Goals
- Good health and well-being
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