Beyond insulin resistance in NASH: TNF-α or adiponectin?
The University of Sydney · Millennium Institute · +2 more institutions
Abstract
Adiponectin has antilipogenic and anti-inflammatory effects, while tumor necrosis factor alpha (TNF-alpha) reduces insulin sensitivity and has proinflammatory effects. We examined (1) the extent to which hypoadiponectinemia and TNF-alpha activation are features of nonalcoholic steatohepatitis (NASH) and (2) whether serum levels of these markers correlate with the severity of histological changes in 109 subjects with nonalcoholic fatty liver disease (NAFLD), including 80 with NASH and 29 with simple steatosis. By multivariate analysis, subjects with NASH had reduced adiponectin level and increased TNF-alpha and soluble TNF receptor 2 (sTNFR2)-but not leptin levels, compared with controls matched by age, sex,…
Citation impact
- FWCI
- 37.87
- Percentile
- 100%
- References
- 55
Authors
6- JMJason M. Hui
The University of Sydney, Millennium Institute, Westmead Hospital
- AHAlex Hodge
The University of Sydney, Millennium Institute, Westmead Hospital
- GCGeoffrey C. Farrell
The University of Sydney, Millennium Institute, Westmead Hospital
- JGJames G. Kench
Westmead Hospital
- ADAdamandia D. Kriketos
Garvan Institute of Medical Research
Topics & keywords
- Adiponectin
- Internal medicine
- Insulin resistance
- Endocrinology
- Steatosis
- Medicine
- Steatohepatitis
- Fatty liver
- Good health and well-being