Evaluating cell lines as tumour models by comparison of genomic profiles
Memorial Sloan Kettering Cancer Center
Abstract
Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian tumours. Our comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. We identify several rarely used cell lines that more closely…
Citation impact
- FWCI
- 131.34
- Percentile
- 100%
- References
- 57
Authors
5Topics & keywords
- Ovarian cancer
- Cell culture
- Biology
- Cancer cell lines
- Computational biology
- Cancer
- Cancer research
- Cell
- Good health and well-being