Autophagy: process and function

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.

• MO
  Ministry of Education, Culture, Sports, Science and Technology
• KM
  Kato Memorial Bioscience Foundation
• TS
  Toray Science Foundation
• JS
  Japan Society for the Promotion of Science