reviewAnnals of the New York Academy of SciencesAug 1, 2009BRONZE OA

Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer

BBBharat B. AggarwalABAjaikumar B. KunnumakkaraKBKuzhuvelil B. HarikumarSRShan R. GuptaSTSheeja T. Tharakan

The University of Texas MD Anderson Cancer Center

PubMed
Indexed incrossrefpubmed

Abstract

Signal transducer and activator of transcription-3 (STAT-3) is one of six members of a family of transcription factors. It was discovered almost 15 years ago as an acute-phase response factor. This factor has now been associated with inflammation, cellular transformation, survival, proliferation, invasion, angiogenesis, and metastasis of cancer. Various types of carcinogens, radiation, viruses, growth factors, oncogenes, and inflammatory cytokines have been found to activate STAT-3. STAT-3 is constitutively active in most tumor cells but not in normal cells. Phosphorylation of STAT-3 at tyrosine 705 leads to its dimerization, nuclear translocation, DNA binding, and gene transcription. The phosphorylation of…

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646
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Authors

8

Topics & keywords

Topics
Keywords
  • Cancer research
  • STAT protein
  • Transcription factor
  • stat
  • STAT3
  • Angiogenesis
  • Biology
  • STAT4
UN Sustainable Development Goals
  • Good health and well-being
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