articleProceedings of the National Academy of SciencesMar 16, 2012Closed access

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

DSDavid SebastiánMIMaría Isabel Hernández‐ÁlvarezJSJessica SegalésESEleonora SorianelloJPJuan Pablo Muñoz

Instituto de Salud Carlos III · Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · +6 more institutions

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Abstract

Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates in mitochondrial fusion and undergoes repression in muscle from obese or type 2 diabetic patients. Here, we provide in vivo evidence that Mfn2 plays an essential role in metabolic homeostasis. Liver-specific ablation of Mfn2 in mice led to numerous metabolic abnormalities, characterized by glucose intolerance and enhanced hepatic gluconeogenesis. Mfn2 deficiency impaired insulin signaling in liver and muscle. Furthermore, Mfn2 deficiency was associated with endoplasmic…

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658
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100%
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Authors

15

Topics & keywords

Topics
Keywords
  • MFN2
  • Endoplasmic reticulum
  • mitochondrial fusion
  • Mitochondrion
  • Glucose homeostasis
  • Cell biology
  • Biology
  • Insulin receptor
UN Sustainable Development Goals
  • Affordable and clean energy
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