The PI3K Pathway As Drug Target in Human Cancer

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, including somatic mutation and amplification of genes encoding key components. In addition, PI3K signaling may serve integral functions for noncancerous cells in the tumor microenvironment. Consequently, therapeutics targeting the PI3K pathway are being developed at a rapid pace, and preclinical and early clinical studies are beginning to suggest specific strategies to effectively use them. However, the central role of PI3K signaling in a large array of diverse biologic processes raises concerns about its use in…

• AA
  American Association for Cancer Research
• DC
  Dana-Farber/Harvard Cancer Center
• NI
  National Institutes of Health

  Awards: P50CA090578, R01CA137008, P50 CA127003
• G
  Genentech
• SU
  Stand Up To Cancer
• NC
  National Cancer Institute

  Awards: CA127003, P50CA090578, P50 CA127003