Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Abstract Introduction Intracellular pH regulation controls energy balance and cell proliferation: chemical and biological proof of principle Oncogene activation and transformation cause acidosis Hypoxia promotes acidosis by shifting from oxidative phosphorylation to glycolytic metabolism Hypoxia enhances the expression and activity of pHi‐regulating systems to promote cell survival and invasion Strategies taking advantage of changes in the oxygen level, energy balance and pH homeostasis to target primary tumours and metastases Conclusion Maintenance of cellular pH homeostasis is fundamental to life. A number of key intracellular pH (pHi) regulating systems including the Na + /H + exchangers, the proton pump,…

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  Sanofi