Making heads or tails of phospholipids in mitochondria
University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · +3 more institutions
Abstract
Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel…
Citation impact
- FWCI
- 26.20
- Percentile
- 100%
- References
- 123
Authors
3- COChristof OsmanCorresponding
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
- DRDennis R. Voelker
National Jewish Health, University of Colorado Denver
- TLThomas Langer
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Max Planck Institute for Biology of Ageing
Topics & keywords
- Cardiolipin
- Biology
- Mitochondrion
- Cell biology
- Mitochondrial membrane transport protein
- Endoplasmic reticulum
- Translocase of the inner membrane
- mitochondrial fusion
- Affordable and clean energy