Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
University College London · Diabetes UK · +7 more institutions
Abstract
Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. Our results demonstrate that S6K1…
Citation impact
- FWCI
- 25.28
- Percentile
- 100%
- References
- 29
Authors
22- CSColin SelmanCorresponding
University College London, Diabetes UK
- JMJennifer M. A. Tullet
MRC Unit for Lifelong Health and Ageing, University College London
- DWDaniela Wieser
European Bioinformatics Institute, Wellcome Trust
- EEElaine E. Irvine
University College London, Diabetes UK
- SJSteven J. Lingard
University College London, Diabetes UK
Topics & keywords
- P70-S6 Kinase 1
- AMPK
- Ribosomal protein s6
- mTORC1
- Biology
- Protein kinase A
- PI3K/AKT/mTOR pathway
- Ribosomal s6 kinase