Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization

Yıldız, Ahmet; Forkey, Joseph N.; McKinney, Sean; Ha, Taekjip; Goldman, Yale E.; Selvin, Paul R.

doi:10.1126/science.1084398

articleScienceJun 9, 2003Closed access

Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization

AYAhmet Yıldız JNJoseph N. Forkey SMSean McKinney THTaekjip Ha YEYale E. Goldman

University of Illinois Urbana-Champaign · University of Pennsylvania

PubMed

Indexed incrossrefpubmed

Abstract

Myosin V is a dimeric molecular motor that moves processively on actin, with the center of mass moving approximately 37 nanometers for each adenosine triphosphate hydrolyzed. We have labeled myosin V with a single fluorophore at different positions in the light-chain domain and measured the step size with a standard deviation of

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Percentile: 100%
References: 31

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Authors

AY
Ahmet Yıldız
University of Illinois Urbana-Champaign, University of Pennsylvania
JN
Joseph N. Forkey
University of Illinois Urbana-Champaign, University of Pennsylvania
SM
Sean McKinney
University of Illinois Urbana-Champaign, University of Pennsylvania
TH
Taekjip Ha
University of Illinois Urbana-Champaign, University of Pennsylvania
YE
Yale E. Goldman
University of Illinois Urbana-Champaign, University of Pennsylvania

Topics & keywords

Topics

Cardiomyopathy and Myosin Studies100%
ATP Synthase and ATPases Research100%
Force Microscopy Techniques and Applications100%

Keywords

Fluorophore
Myosin
Chemistry
Biophysics
Fluorescence
Physics
Optics
Biology

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