Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing…

• NS
  National Science Foundation
• AC
  American Cancer Society
• AF
  Avon Foundation for Women
• BC
  Breast Cancer Research Foundation

  Award: 90047965
• PU
  Purdue University
• CF
  Center for Hierarchical Manufacturing, National Science Foundation

  Award: C301/A14762
• TU
  Temple University
• PU
  Purdue University Center for Cancer Research
• CR
  Cancer Research UK

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• UO
  University of Glasgow
• MO
  Ministry of Education, Culture, Sports, Science and Technology

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  Terry Fox Foundation
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  Federación Española de Enfermedades Raras
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  Ministero della Salute

  Award: GR-2011-02348047
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca
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  Ministerio de Ciencia e Innovación
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  Associazione Italiana per la Ricerca sul Cancro

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• UA
  United Arab Emirates University
• JD
  Junta de Castilla y León
• NI
  National Institutes of Health

  Awards: AI076535, CA109335, R01 CA109335-04A1