Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients
University of Leicester · Prevention Group · +1 more institution
Abstract
Resveratrol is a phytochemical with chemopreventive activity in preclinical rodent models of colorectal carcinogenesis. Antiproliferation is one of the many chemopreventive modes of action it has been shown to engage in. Concentrations of resveratrol, which can be achieved in human tissues after p.o. administration, have not yet been defined. The purpose of this study was to measure concentrations of resveratrol and its metabolites in the colorectal tissue of humans who ingested resveratrol. Twenty patients with histologically confirmed colorectal cancer consumed eight daily doses of resveratrol at 0.5 or 1.0 g before surgical resection. Resveratrol was found to be well tolerated. Normal and malignant biopsy…
Citation impact
- FWCI
- 14.92
- Percentile
- 100%
- References
- 28
Authors
14- KPKetan PatelCorresponding
University of Leicester, Prevention Group, National Cancer Institute
- VBVictoria Brown
University of Leicester, Prevention Group, National Cancer Institute
- DJDonald J. L. Jones
University of Leicester, Prevention Group, National Cancer Institute
- RGRobert G. Britton
University of Leicester, Prevention Group, National Cancer Institute
- DHDavid Hemingway
University of Leicester, Prevention Group, National Cancer Institute
Topics & keywords
- Resveratrol
- Pharmacology
- Glucuronide
- Chemistry
- Colorectal cancer
- Metabolite
- Cancer
- Medicine
- Good health and well-being