Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
University of New Mexico · Duke University · +2 more institutions
Abstract
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Citation impact
- FWCI
- 39.19
- Percentile
- 100%
- References
- 24
Authors
4- SSSudha Singh
University of New Mexico, Duke University, Geriatric Research Education and Clinical Center, Durham VA Medical Center
- ASAlexander S. Davis
University of New Mexico, Duke University, Geriatric Research Education and Clinical Center, Durham VA Medical Center
- GAGregory A. Taylor
University of New Mexico, Duke University, Geriatric Research Education and Clinical Center, Durham VA Medical Center
- VDVojo DeretićCorresponding
University of New Mexico, Duke University, Geriatric Research Education and Clinical Center, Durham VA Medical Center
Topics & keywords
- Intracellular
- Autophagy
- Intracellular parasite
- Guanosine
- Cell biology
- Organelle
- Biology
- Mycobacterium tuberculosis
- Good health and well-being