Regulation of Mammalian Autophagy in Physiology and Pathophysiology
University of Cambridge · Addenbrooke's Hospital
Abstract
(Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned structures, which engulf portions of cytoplasm. The resulting autophagosomes ultimately fuse with lysosomes, where their contents are degraded. Although the term autophagy was first used in 1963, the field has witnessed dramatic growth in the last 5 years, partly as a consequence of the discovery of key components of its cellular machinery. In this review we focus on mammalian autophagy, and we give an overview of the understanding of its machinery and the signaling cascades that regulate it. As recent studies have also shown that autophagy is critical in…
Citation impact
- FWCI
- 65.39
- Percentile
- 100%
- References
- 613
Authors
19- BRBrinda RavikumarCorresponding
University of Cambridge, Addenbrooke's Hospital
- SSSovan Sarkar
University of Cambridge, Addenbrooke's Hospital
- JEJ. Eric Davies
University of Cambridge, Addenbrooke's Hospital
- MFMarie Futter
University of Cambridge, Addenbrooke's Hospital
- MGMoisés Garcı́a-Arencibia
University of Cambridge, Addenbrooke's Hospital
Topics & keywords
- Autophagy
- Cell biology
- Neurodegeneration
- ATG16L1
- Biology
- Organelle
- Epiphenomenon
- Disease
- Good health and well-being