Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model

The human gut is colonized by a complex microbiota with multiple benefits. Although the surface-attached, mucosal microbiota has a unique composition and potential to influence human health, it remains difficult to study in vivo. Therefore, we performed an in-depth microbial characterization (human intestinal tract chip (HITChip)) of a recently developed dynamic in vitro gut model, which simulates both luminal and mucosal gut microbes (mucosal-simulator of human intestinal microbial ecosystem (M-SHIME)). Inter-individual differences among human subjects were confirmed and microbial patterns unique for each individual were preserved in vitro. Furthermore, in correspondence with in vivo studies, Bacteroidetes…

• UO
  University of Aberdeen
• FW
  Fonds Wetenschappelijk Onderzoek

  Award: BOF12/GOA/008
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek
• UG
  Universiteit Gent
• VR
  Vlaamse regering
• BO
  Bijzonder Onderzoeksfonds UGent

  Award: BOF12/GOA/008