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Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
UNSW Sydney · Department of Medical Sciences · +6 more institutions
Abstract
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an important redox carrier, NAD+ also serves as the sole substrate for NAD-dependent enzymes, including poly(ADP-ribose) polymerase (PARP), an important DNA nick sensor, and NAD-dependent histone deacetylases, Sirtuins which play an important role in a wide variety of processes, including senescence, apoptosis, differentiation, and aging. We examined the effect of aging on intracellular NAD+ metabolism in the whole heart, lung, liver and kidney of female wistar rats. Our results are the first to show a significant decline in intracellular NAD+ levels and…
Citation impact
- FWCI
- 17.01
- Percentile
- 100%
- References
- 81
Authors
6- NBNady Braidy
UNSW Sydney
- GJGilles J. Guillemin
Department of Medical Sciences, St Vincent's Clinic, St. Vincent's Medical Center, UNSW Sydney, St Vincents Institute of Medical Research
- HMHussein Mansour
Institute of Neurobiology, University of Sydney
- TCTailoi Chan‐Ling
University of Sydney, Institute of Neurobiology
- APAnne Poljak
UNSW Sydney
Topics & keywords
- Oxidative stress
- NAD+ kinase
- Metabolism
- Energy metabolism
- Oxidative metabolism
- Oxidative phosphorylation
- Chemistry
- Biochemistry