An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

Skeletal muscle adapts to chronic physical activity by inducing mitochondrial biogenesis and switching proportions of muscle fibers from type II to type I. Several major factors involved in this process have been identified, such as the calcium/calmodulin-dependent protein kinase IV (CaMKIV), calcineurin A (CnA), and the transcriptional component peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha). Transgenic expression of PGC-1alpha recently has been shown to dramatically increase the content of type I muscle fibers in skeletal muscle, but the relationship between PGC-1alpha expression and the key components in calcium signaling is not clear. In this report, we show that the…

• NS
  National Science Foundation
• AH
  American Heart Association
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• NI
  National Institutes of Health

  Award: DK54477