Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

SIGNIFICANCE: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory form of cell death, pyroptosis. In response to infection or cellular stress, inflammasomes are assembled, activated, and involved in host defense and pathophysiology of diseases. Clarification of the molecular mechanisms leading to the activation of this intracellular inflammatory machinery may provide new insights into the concept of inflammation as the root of and route to human diseases. RECENT ADVANCES: The activation of inflammasomes, specifically the most…

• NI
  National Institutes of Health

  Awards: HL57244, DK54927, 1F31AG043289, HL091464, HL075316, 1F31AG043289-01