reviewCold Spring Harbor Perspectives in BiologySep 1, 2012BRONZE OA

PI3K-PKB/Akt Pathway

BABrian A. HemmingsDFDavid F. Restuccia

Friedrich Miescher Institute

PubMed
Indexed incrossrefpubmed

Abstract

Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).

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1,047
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16
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Authors

2

Topics & keywords

Topics
Keywords
  • Protein kinase B
  • Biology
  • PI3K/AKT/mTOR pathway
  • Cell biology
  • Phosphoinositide 3-kinase
  • Kinase
  • Proto-Oncogene Proteins c-akt
  • Cell growth
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