Maternal Genistein Alters Coat Color and Protects A vy Mouse Offspring from Obesity by Modifying the Fetal Epigenome
Duke University · Institut thématique Génétique, génomique et bioinformatique · +2 more institutions
Abstract
Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive performance and to cancer chemoprevention and decreased adipose deposition. Dietary genistein may also play a role in the decreased incidence of cancer in Asians compared with Westerners, as well as increased cancer incidence in Asians immigrating to the United States. Here, we report that maternal dietary genistein supplementation of mice during gestation, at levels comparable with humans consuming high-soy diets, shifted the coat color of heterozygous viable yellow agouti (A(vy/a) offspring toward pseudoagouti. This marked phenotypic change was significantly associated with increased methylation of six cytosine-guanine…
Citation impact
- FWCI
- 34.73
- Percentile
- 100%
- References
- 47
Authors
4- DCDana C. DolinoyCorresponding
Duke University, Institut thématique Génétique, génomique et bioinformatique, Duke Medical Center
- JWJennifer Weidman
Institut thématique Génétique, génomique et bioinformatique, Duke Medical Center
- RARobert A. Waterland
Baylor College of Medicine
- RLRandy L. Jirtle
Duke University, Institut thématique Génétique, génomique et bioinformatique, Duke Medical Center
Topics & keywords
- Genistein
- Offspring
- Epigenome
- Biology
- Endocrinology
- DNA methylation
- Internal medicine
- Epigenetics