Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, Samar I.; Ruderman, Neil B.; Schmieder, Frank; Boden, Guenther

doi:10.2337/diabetes.51.7.2005

articleDiabetesJul 1, 2002BRONZE OA

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

SISamar I. Itani NBNeil B. Ruderman FSFrank Schmieder GBGuenther Boden

Boston University · Boston Medical Center · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The possibility that lipid-induced insulin resistance in human muscle is related to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels were increased by a lipid/heparin infusion. In keeping with previous reports, rates of insulin-stimulated glucose disappearance (G(Rd)) were normal after 2 h but were reduced by 43% (from 52.7 +/- 8.2 to 30.0 +/- 5.3 micromol. kg(-1). min(-1), P

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Topics & keywords

Topics

Keywords

Diacylglycerol kinase
Internal medicine
Endocrinology
Protein kinase C
Insulin resistance
Ceramide
Diglyceride
Insulin receptor

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