articleDiabetesJan 1, 2003Closed access

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

AEAlexandra E. ButlerJJJuliette JansonSBSusan Bonner‐WeirRRRobert RitzelRARobert A. Rizza

University of Southern California · Karolinska Institutet · +3 more institutions

PubMed
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Abstract

Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in beta-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m(2); 41 with type 2 diabetes, 15 with impaired fasting glucose [IFG], and 35 nondiabetic subjects) and 33 lean cases (BMI

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Topics & keywords

Topics
Keywords
  • Neogenesis
  • Internal medicine
  • Endocrinology
  • Diabetes mellitus
  • Type 2 diabetes
  • Medicine
  • Beta cell
  • Obesity
UN Sustainable Development Goals
  • Good health and well-being
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