Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically developing world. The adverse toxicological consequences of these compounds in populations are quite varied because of a wide range of exposures leading to acute effects, including rapid death, and chronic outcomes such as hepatocellular carcinoma. Furthermore, emerging studies describe a variety of general adverse health effects associated with aflatoxin, such as impaired growth in children. Aflatoxin exposures have also been demonstrated to multiplicatively increase the risk of liver cancer in people chronically infected with hepatitis B virus (HBV)…

• NI
  National Institutes of Health

  Award: P01 ES006052
• NC
  National Cancer Institute

  Award: CA39416
• NI
  National Institute of Environmental Health Sciences

  Award: P01 ES006052