TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

Bhola, Neil E.; Balko, Justin M.; Dugger, Teresa C.; Kuba, M. Gabriela; Sánchez, Violeta; Sanders, Melinda E.; Stanford, Jamie C.; Cook, Rebecca S.; Arteaga, Carlos L.

doi:10.1172/jci65416

articleJournal of Clinical InvestigationFeb 8, 2013BRONZE OA

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

NENeil E. Bhola JMJustin M. Balko TCTeresa C. Dugger MGM. Gabriela Kuba VSVioleta Sánchez

Vanderbilt University · Breast Cancer Research Foundation

PubMed

Indexed incrossrefdoajpubmed

Abstract

After an initial response to chemotherapy, many patients with triple-negative breast cancer (TNBC) have recurrence of drug-resistant metastatic disease. Studies with TNBC cells suggest that chemotherapy-resistant populations of cancer stem-like cells (CSCs) with self-renewing and tumor-initiating capacities are responsible for these relapses. TGF-β has been shown to increase stem-like properties in human breast cancer cells. We analyzed RNA expression in matched pairs of primary breast cancer biopsies before and after chemotherapy. Biopsies after chemotherapy displayed increased RNA transcripts of genes associated with CSCs and TGF-β signaling. In TNBC cell lines and mouse xenografts, the chemotherapeutic drug…

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Topics & keywords

Topics

Keywords

Triple-negative breast cancer
Chemotherapy
Breast cancer
Medicine
Action (physics)
Internal medicine
Cancer research
Oncology

UN Sustainable Development Goals

Good health and well-being

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