articleThe Journal of Experimental MedicineSep 22, 2008BRONZE OA

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

AEAssam El‐OstaDBDaniella BrasacchioDYDachun YaoAPAlessandro PocaiPLPeter Lloyd Jones

Baker Heart and Diabetes Institute · Juvenile Diabetes Research Foundation · +3 more institutions

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Abstract

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains

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Topics & keywords

Topics
Keywords
  • Epigenetics
  • Endocrinology
  • Internal medicine
  • Diabetes mellitus
  • Gene expression
  • Biology
  • Medicine
  • Gene
UN Sustainable Development Goals
  • Good health and well-being
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