Lysophospholipid Receptors: Signaling and Biology
Scripps Research Institute · Hokkaido University · +1 more institution
Abstract
Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and…
Citation impact
- FWCI
- 19.28
- Percentile
- 100%
- References
- 213
Authors
4- IIIsao IshiiCorresponding
Scripps Research Institute, Hokkaido University, National Center of Neurology and Psychiatry
- NFNobuyuki Fukushima
Scripps Research Institute, Hokkaido University, National Center of Neurology and Psychiatry
- XYXiaoqin Ye
Scripps Research Institute, Hokkaido University, National Center of Neurology and Psychiatry
- JCJerold Chun
Scripps Research Institute, Hokkaido University, National Center of Neurology and Psychiatry
Topics & keywords
- Lysophosphatidic acid
- Receptor
- Cell biology
- Biology
- Angiogenesis
- Lipid signaling
- Signal transduction
- G protein-coupled receptor