An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
Kyung Hee University · Samsung Medical Center · +1 more institution
Indexed incrossrefpubmed
Abstract
Background
Recent evidence indicates that the composition of the gut microbiota contributes to the development of metabolic disorders by affecting the physiology and metabolism of the host. Metformin is one of the most widely prescribed type 2 diabetes (T2D) therapeutic agents.
Objective
To determine whether the antidiabetic effect of metformin is related to alterations of intestinal microbial composition.
Citation impact
1,547
total citations
- FWCI
- 31.11
- Percentile
- 100%
- References
- 59
Citations per year
Authors
7Topics & keywords
Keywords
- Metformin
- Akkermansia
- Akkermansia muciniphila
- Glucose homeostasis
- Gut flora
- Internal medicine
- Endocrinology
- Type 2 diabetes
UN Sustainable Development Goals
- Good health and well-being
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