The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization
Broad Institute · Purdue University West Lafayette · +16 more institutions
Abstract
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually…
Citation impact
- FWCI
- 52.00
- Percentile
- 100%
- References
- 16
Authors
45- CAChristina A. CuomoCorresponding
Broad Institute, Purdue University West Lafayette, Weihenstephan-Triesdorf University of Applied Sciences, Institute of Bioinformatics and Systems Biology, Technical University of Munich, Massachusetts Institute of Technology, Michigan State University
- UGUlrich Güldener
Broad Institute, Purdue University West Lafayette, Weihenstephan-Triesdorf University of Applied Sciences, Institute of Bioinformatics and Systems Biology, Technical University of Munich, Massachusetts Institute of Technology, Michigan State University
- JXJin‐Rong Xu
Broad Institute, Purdue University West Lafayette, Weihenstephan-Triesdorf University of Applied Sciences, Institute of Bioinformatics and Systems Biology, Technical University of Munich, Massachusetts Institute of Technology, Michigan State University
- FTFrances Trail
Broad Institute, Purdue University West Lafayette, Weihenstephan-Triesdorf University of Applied Sciences, Institute of Bioinformatics and Systems Biology, Technical University of Munich, Massachusetts Institute of Technology, Michigan State University
- BGB. Gillian Turgeon
Broad Institute, Cornell University, Purdue University West Lafayette, Weihenstephan-Triesdorf University of Applied Sciences, Institute of Bioinformatics and Systems Biology, Technical University of Munich, Massachusetts Institute of Technology, Michigan State University
Topics & keywords
- Biology
- Genetics
- Genome
- Gene
- Fusarium
- Mutant
- Pathogen
- Industry, innovation and infrastructure