Insights from 20 years of bacterial genome sequencing
Oak Ridge National Laboratory · University of Tennessee at Knoxville · +3 more institutions
Abstract
Since the first two complete bacterial genome sequences were published in 1995, the science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is possible to completely sequence a bacterial genome in a few hours and identify some types of methylation sites along the genome as well. Sequencing of bacterial genome sequences is now a standard procedure, and the information from tens of thousands of bacterial genomes has had a major impact on our views of the bacterial world. In this review, we explore a series of questions to highlight some insights that comparative genomics has produced. To date, there are genome sequences available from 50 different bacterial phyla and 11 different…
Citation impact
- FWCI
- 35.69
- Percentile
- 100%
- References
- 170
Authors
12- MLMiriam LandCorresponding
Oak Ridge National Laboratory
- LHLoren Hauser
University of Tennessee at Knoxville, Oak Ridge National Laboratory, Joint Institute for Computational Sciences
- SJSe‐Ran Jun
Oak Ridge National Laboratory
- INIntawat Nookaew
Oak Ridge National Laboratory
- MRMichael R. Leuze
Oak Ridge National Laboratory
Topics & keywords
- Biology
- Phylum
- Genome
- Bacterial genome size
- DNA sequencing
- Genetics
- Comparative genomics
- Metagenomics
- Good health and well-being
Funding
- UDU.S. Department of EnergyAwards: AC05-00OR22725, . DE-AC05-00OR22725, No. DE-AC05-00OR22725, DE-AC05, DE-PS02-06ER64304, 00OR22725
- BBattelleAwards: DE-AC05, DE-AC05-00OR22725
- UUT-BattelleAwards: DE-AC05-, No. DE-AC05-00OR22725, AC05-00OR22725
- OOOffice of ScienceAwards: DE-AC05-00OR22725, No. DE-AC05-00OR22725, DE-PS02-06ER64304, AC05-00OR22725
- BABiological and Environmental ResearchAwards: DE-AC05-00OR22725, 00OR22725, DE-PS02-06ER64304
- OROak Ridge National LaboratoryAwards: AC05-00OR22725, DE-PS02-06ER64304