articleMolecular Biology of the CellJan 3, 2013GREEN OA

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

OCOliver C. LosónZSZhiyin SongHCHsiuchen ChenDCDavid C. Chan

California Institute of Technology · Howard Hughes Medical Institute

PubMed
Indexed incrossrefpubmed

Abstract

Several mitochondrial outer membrane proteins-mitochondrial fission protein 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51, respectively)-have been proposed to promote mitochondrial fission by recruiting the GTPase dynamin-related protein 1 (Drp1), but fundamental issues remain concerning their function. A recent study supported such a role for Mff but not for Fis1. In addition, it is unclear whether MiD49 and MiD51 activate or inhibit fission, because their overexpression causes extensive mitochondrial elongation. It is also unknown whether these proteins can act in the absence of one another to mediate fission. Using Fis1-null, Mff-null, and…

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Topics & keywords

Topics
Keywords
  • FIS1
  • Mitochondrial fission
  • Biology
  • Cell biology
  • Fission
  • Mitochondrion
  • GTPase
  • mitochondrial fusion
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