A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

Shim, Heejung; Chasman, Daniel I.; Smith, Joshua D.; Mora, Samia; Ridker, Paul M.; Nickerson, Deborah A.; Krauss, Ronald M.; Stephens, Matthew

doi:10.1371/journal.pone.0120758

articlePLoS ONEApr 21, 2015GOLD OA

A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

HSHeejung Shim DIDaniel I. Chasman JDJoshua D. Smith SMSamia Mora PMPaul M. Ridker

University of Chicago · Harvard University · +2 more institutions

PubMed

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Abstract

We conducted a genome-wide association analysis of 7 subfractions of low density lipoproteins (LDLs) and 3 subfractions of intermediate density lipoproteins (IDLs) measured by gradient gel electrophoresis, and their response to statin treatment, in 1868 individuals of European ancestry from the Pharmacogenomics and Risk of Cardiovascular Disease study. Our analyses identified four previously-implicated loci (SORT1, APOE, LPA, and CETP) as containing variants that are very strongly associated with lipoprotein subfractions (log(10)Bayes Factor > 15). Subsequent conditional analyses suggest that three of these (APOE, LPA and CETP) likely harbor multiple independently associated SNPs. Further, while different…

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Topics & keywords

Topics

Keywords

Genome-wide association study
Single-nucleotide polymorphism
SNP
Biology
Genetic association
Genetics
Statin
Gene

UN Sustainable Development Goals

Good health and well-being

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