A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1

Shaughnessy, John D.; Zhan, Fenghuang; Burington, Bart; Huang, Yongsheng; Colla, Simona; Hanamura, Ichiro; Stewart, Peter; Kordsmeier, Bob; Randolph, Christopher E.; Williams, David R.; Xiao, Yan; Xu, Hongwei; Epstein, Joshua; Anaissie, Elias; Krishna, Somashekar G.; Cottler‐Fox, Michele; Hollmig, Klaus; Mohiuddin, Abid; Pineda‐Roman, Mauricio; Tricot, Guido; Rhee, Frits van; Sawyer, Jeffrey R.; Alsayed, Yazan; Walker, Ronald C.; Zangari, Maurizio; Crowley, John; Barlogie, Bart

doi:10.1182/blood-2006-07-038430

articleBloodNov 14, 2006Closed access

A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1

JDJohn D. Shaughnessy FZFenghuang Zhan BBBart Burington YHYongsheng Huang SCSimona Colla

University of Arkansas for Medical Sciences · Cancer Research And Biostatistics

PubMed

Indexed incrossrefpubmed

Abstract

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to chromosome 1 (P

Citation impact

915

total citations

FWCI: 17.91
Percentile: 100%
References: 33

Citations per year

Authors

27

Topics & keywords

Topics

Keywords

Hazard ratio
Oncology
Proportional hazards model
Gene expression profiling
Internal medicine
Biology
Framingham Risk Score
Gene

UN Sustainable Development Goals

Reduced inequalities

No related works found for this paper.