reviewCancer Prevention ResearchOct 13, 2010Closed access

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

Mount Sinai Hospital · University of Toronto · +3 more institutions

PubMed
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Abstract

Metformin, an insulin-lowering agent, has been associated with decreased cancer risk in epidemiologic studies in diabetic patients. We performed a comprehensive literature search and meta-analysis of epidemiologic studies to assess the effect of metformin on cancer incidence and mortality in diabetic patients, using Pubmed, ISI Web of Science, Embase, and the Cochrane library until May 2009, with no language or time restrictions. Independent reports with sufficient information to allow risk estimation of cancer risk/mortality and a measure of uncertainty were reviewed and cross-checked independently by three investigators. Eleven studies were selected for relevance in terms of intervention, population studied,…

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