Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin
Boston University · Daiichi Sankyo (Germany) · +2 more institutions
Abstract
Adiponectin is an adipocyte-derived, antiatherogenic protein that is present in serum as three isoforms. Total adiponectin levels are decreased in obese or diabetic humans or animal models. This study was designed to elucidate the relative isoform distribution of adiponectin in human disease states and identify the active form of adiponectin toward vascular endothelial cells. The percentage of high molecular weight form (HMW) per total adiponectin was significantly lower in patients with coronary artery disease than control subjects, whereas the hexamer form was similar and the trimer form was significantly higher. During weight reduction in obese subjects, the HMW form increased and the trimer and hexamer…
Citation impact
- FWCI
- 29.01
- Percentile
- 100%
- References
- 24
Authors
8- HKHideki KobayashiCorresponding
Boston University, Daiichi Sankyo (Germany), Biomedical Research Laboratories (United States), The University of Osaka
- NONoriyuki Ouchi
Boston University, Daiichi Sankyo (Germany), Biomedical Research Laboratories (United States), The University of Osaka
- SKShinji Kihara
Boston University, Daiichi Sankyo (Germany), Biomedical Research Laboratories (United States), The University of Osaka
- KWKenneth Walsh
Boston University, Daiichi Sankyo (Germany), Biomedical Research Laboratories (United States), The University of Osaka
- MKMasahiro Kumada
Boston University, Daiichi Sankyo (Germany), Biomedical Research Laboratories (United States), The University of Osaka
Topics & keywords
- Adiponectin
- Apoptosis
- Endothelial stem cell
- Cell biology
- Internal medicine
- Cell
- Endocrinology
- Chemistry
- Good health and well-being