Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
University of Cologne · Max Planck Institute for Biology of Ageing · +9 more institutions
Abstract
A change of heart (mitochondria) Mitochondria provide an essential source of energy to drive cellular processes and are particularly important in heart muscle cells (see the Perspective by Gottlieb and Bernstein). After birth, the availability of oxygen and nutrients to organs and tissues changes. This invokes changes in metabolism. Gong et al. studied the developmental transitions in mouse heart mitochondria soon after birth. Mitochondria were replaced wholesale via mitophagy in cardiomyocytes over the first 3 weeks after birth. Preventing this turnover by interfering with parkin-mediated mitophagy specifically in cardiomyocytes prevented the normal metabolic transition and caused heart failure. Thus, the…
Citation impact
- FWCI
- 17.92
- Percentile
- 100%
- References
- 72
Authors
10- TWTimothy WaiCorresponding
University of Cologne, Max Planck Institute for Biology of Ageing
- JGJaime García‐PrietoCorresponding
Spanish National Centre for Cardiovascular Research
- MJMichael J. Baker
University of Cologne
- CMCarsten Merkwirth
University of Cologne
- PBPaule Bénit
Inserm, Délégation Paris 7, Université Paris Cité, Hôpital Robert-Debré, NeuroDiderot
Topics & keywords
- Fragmentation (computing)
- Heart failure
- Mitochondrial DNA
- Biology
- Cardiology
- Medicine
- Genetics
- Ecology
- Good health and well-being