Proton pump inhibitors affect the gut microbiome
University Medical Center Groningen · University of Groningen · +2 more institutions
Abstract
The gut microbiome composition of 1815 individuals, spanning three cohorts, was assessed by tag sequencing of the 16S rRNA gene. The difference in microbiota composition in PPI users versus non-users was analysed separately in each cohort, followed by a meta-analysis.
211 of the participants were using PPIs at the moment of stool sampling. PPI use is associated with a significant decrease in Shannon's diversity and with changes in 20% of the bacterial taxa (false discovery rate
Citation impact
- FWCI
- 28.61
- Percentile
- 100%
- References
- 33
Authors
17- FIFloris Imhann
University Medical Center Groningen, University of Groningen
- MJMarc Jan Bonder
University Medical Center Groningen, University of Groningen
- AVArnau Vich Vila
University Medical Center Groningen, University of Groningen
- JFJingyuan Fu
University Medical Center Groningen, University of Groningen
- ZMZlatan Mujagic
Maastricht University
Topics & keywords
- Microbiome
- Biology
- Microbiology
- Enterococcus
- Clostridium difficile
- Streptococcus
- Metagenomics
- Enterococcus faecalis