reviewPhysiological ReviewsAug 13, 2015GREEN OA

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

PBPaolo BernardiARAndrea RasolaMFMichael ForteGLGiovanna Lippe

University of Udine · Oregon Health & Science University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca(2+)-dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide…

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561
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29.51
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100%
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682
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Authors

4

Topics & keywords

Topics
Keywords
  • Mitochondrial permeability transition pore
  • Cell biology
  • Signal transduction
  • Biology
  • Mitochondrion
  • ATP synthase
  • Biophysics
  • Bioenergetics
UN Sustainable Development Goals
  • Affordable and clean energy
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