Aldehyde dehydrogenase 1A1 in stem cells and cancer

// Hiroyuki Tomita 1 , Kaori Tanaka 1,2 , Takuji Tanaka 3 and Akira Hara 1 1 Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan 2 Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan 3 Division of Pathology, Gifu Municipal Hospital, Gifu, Japan Correspondence to: Hiroyuki Tomita, email: // Keywords : aldehyde dehydrogenase, ALDH, ALDH1A1, cancer, stem cell Received : July 11, 2015 Accepted : January 07, 2016 Published : January 15, 2016 Abstract The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH) genes, which encode enzymes critical for detoxification of endogenous and exogenous aldehyde substrates through…