Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy
Union Hospital · Heidelberg University · +5 more institutions
Abstract
Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell signaling. Mitochondria in malignant cells differ structurally and functionally from those in normal cells and participate actively in metabolic reprogramming. Mitochondria in cancer cells are characterized by reactive oxygen species (ROS) overproduction, which promotes cancer development by inducing genomic instability, modifying gene expression, and participating in signaling pathways. Mitochondrial and nuclear DNA mutations caused by oxidative damage that impair the oxidative phosphorylation process will result in further mitochondrial ROS production, completing the "vicious cycle" between mitochondria, ROS, genomic…
Citation impact
- FWCI
- 17.93
- Percentile
- 100%
- References
- 148
Authors
7- YYYuhui Yang
Union Hospital, Heidelberg University, Wuhan Union Hospital, Union Hospital, Huazhong University of Science and Technology
- SKSvetlana Karakhanova
Heidelberg University
- WHWerner Hartwig
Ludwig-Maximilians-Universität München
- JDJan D’Haese
Ludwig-Maximilians-Universität München
- PPPavel P. Philippov
Lomonosov Moscow State University
Topics & keywords
- Mitochondrion
- Oxidative phosphorylation
- Cancer cell
- Cell biology
- Mitochondrial ROS
- Biology
- Reactive oxygen species
- Apoptosis
- Good health and well-being