Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
German Institute of Human Nutrition · Freie Universität Berlin
Abstract
A subclinical inflammatory reaction has been shown to precede the onset of type 2 (non-insulin-dependent) diabetes. We therefore examined prospectively the effects of the central inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) on the development of type 2 diabetes. We designed a nested case-control study within the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study including 27,548 individuals. Case subjects were defined to be those who were free of type 2 diabetes at baseline and subsequently developed type 2 diabetes during a 2.3-year follow-up period. A total of 192 cases of incident type 2 diabetes…
Citation impact
- FWCI
- 23.62
- Percentile
- 100%
- References
- 25
Authors
8- JSJoachim SprangerCorresponding
German Institute of Human Nutrition, Freie Universität Berlin
- AKAnja Kroke
German Institute of Human Nutrition
- MMMatthias Möhlig
German Institute of Human Nutrition, Freie Universität Berlin
- KHKurt Hoffmann
German Institute of Human Nutrition
- MMManuela M. Bergmann
German Institute of Human Nutrition
Topics & keywords
- Type 2 diabetes
- Medicine
- Diabetes mellitus
- Prospective cohort study
- Internal medicine
- Odds ratio
- Quartile
- Population
- Good health and well-being