Antimicrobial Peptides: Mechanisms of Action and Resistance

More than 40 antimicrobial peptides and proteins (AMPs) are expressed in the oral cavity. These AMPs have been organized into 6 functional groups, 1 of which, cationic AMPs, has received extensive attention in recent years for their promise as potential antibiotics. The goal of this review is to describe recent advances in our understanding of the diverse mechanisms of action of cationic AMPs and the bacterial resistance against these peptides. The recently developed peptide GL13K is used as an example to illustrate many of the discussed concepts. Cationic AMPs typically exhibit an amphipathic conformation, which allows increased interaction with negatively charged bacterial membranes. Peptides undergo changes…

• UO
  University of Minnesota

  Award: UL1TR000114
• AN
  Agence Nationale de la Recherche

  Awards: TRANSPEP 07-PCV-0018, 12-BSV5-0012, 14-CE34-0001-01, LabEx Chemistry of Complex Systems 10-LABX-0026_CSC, MemPepSyn 14-CE34-0001-01, 07-PCV-0018, 10-LABX-0026_CSC, membraneDNP 12-BSV5-0012
• FP
  Fondation pour la Recherche Médicale
• UD
  Université de Strasbourg
• CS
  China Scholarship Council
• CN
  Centre National de la Recherche Scientifique
• CR
  Conseil Régional d'Alsace
• NI
  National Institutes of Health

  Awards: UL1TR000114, -0001
• UP
  U.S. Public Health Service
• NC
  National Center for Advancing Translational Sciences

  Award: UL1TR000114