Mitochondrial function as a therapeutic target in heart failure

Brown, David A.; Perry, Justin B.; Allen, Mitchell E.; Sabbah, Hani N.; Stauffer, Brian L.; Shaikh, Saame Raza; Cleland, John G.F.; Colucci, Wilson S.; Butler, Javed; Voors, Adriaan A.; Anker, Stefan D.; Pitt, Bertram; Pieske, Burkert; Filippatos, Gerasimos; Greene, Stephen J.; Gheorghiade, Mihai

doi:10.1038/nrcardio.2016.203

reviewNature Reviews CardiologyDec 22, 2016HYBRID OA

Mitochondrial function as a therapeutic target in heart failure

DADavid A. Brown JBJustin B. Perry MEMitchell E. Allen HNHani N. Sabbah BLBrian L. Stauffer

Virginia Tech · Henry Ford Hospital · +16 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria. Heart failure is a pressing worldwide public-health problem with millions of patients having worsening heart failure. Despite all the available therapies, the condition carries a very poor prognosis. Existing therapies provide symptomatic and clinical benefit, but do not fully address molecular abnormalities that occur…

Citation impact

778

total citations

FWCI: 26.46
Percentile: 100%
References: 256

Citations per year

Authors

16

Topics & keywords

Topics

Keywords

Heart failure
Medicine
Mitochondrion
Bioinformatics
Cardiac function curve
Cardiology
Intensive care medicine
Biology

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.