Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium moiety to a pharmacophore of interest. Other delocalized lipophilic cations, such as rhodamine, natural and synthetic mitochondria-targeting peptides, and nanoparticle vehicles, have also been used for mitochondrial delivery of small molecules. Depending on the approach used, and the cell and mitochondrial membrane potentials, more than 1000-fold higher mitochondrial concentration can be achieved. Mitochondrial…

• AN
  Agence Nationale de la Recherche

  Awards: ANR-16-CE07-0023-01, ANR-09-BLAN-0193-02, ANR-15-CE29-0022-01
• NC
  Narodowe Centrum Nauki

  Award: 2015/18/E/ST4/00235
• NC
  National Cancer Institute

  Awards: U01 CA178960, R01 CA152810