FOXO Signaling Pathways as Therapeutic Targets in Cancer

Many transcription factors play a key role in cellular differentiation and the delineation of cell phenotype. Transcription factors are regulated by phosphorylation, ubiquitination, acetylation/deacetylation and interactions between two or more proteins controlling multiple signaling pathways. These pathways regulate different physiological processes and pathological events, such as cancer and other diseases. The Forkhead box O (FOXO) is one subfamily of the fork head transcription factor family with important roles in cell fate decisions and this subfamily is also suggested to play a pivotal functional role as a tumor suppressor in a wide range of cancers. During apoptosis, FOXOs are involved in…

• NN
  National Natural Science Foundation of China

  Awards: 2011B050200005, MYRG2016-00052-FHS, SRG2015-00004-FHS, 31371088
• UD
  Universidade de Macau

  Awards: MYRG2016-00052-FHS, SRG2015-00004-FHS
• FP
  Fundo para o Desenvolvimento das Ciências e da Tecnologia

  Awards: FDCT016/2016/A1, 021/2015/A1, FDCT 021/2015/A1