Genomic Evolution of Breast Cancer Metastasis and Relapse

Yates, Lucy; Knappskog, Stian; Wedge, David C.; Farmery, James H. R.; González, Santiago; Martincorena, Iñigo; Alexandrov, Ludmil B.; Loo, Peter Van; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazińska, Patrycja; Bhosle, Shriram G.; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor J.; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.M.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J.

doi:10.1016/j.ccell.2017.07.005

articleCancer CellAug 1, 2017HYBRID OA

Genomic Evolution of Breast Cancer Metastasis and Relapse

LYLucy Yates SKStian Knappskog DCDavid C. Wedge JHJames H. R. Farmery SGSantiago González

Guy's Hospital · Wellcome Sanger Institute · +24 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number…

Citation impact

690

total citations

FWCI: 25.70
Percentile: 100%
References: 58

Citations per year

Authors

30

Topics & keywords

Topics

Keywords

Breast cancer
Metastasis
Primary tumor
Metastatic breast cancer
Gene
Cancer
Biology
Cancer research

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.